A Novel Role for an Insect Apolipoprotein (Apolipophorin III) in -1,3-Glucan Pattern Recognition and Cellular Encapsulation Reactions
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A novel role for an insect apolipoprotein (apolipophorin III) in beta-1,3-glucan pattern recognition and cellular encapsulation reactions.
Lipoproteins and molecules for pattern recognition are centrally important in the innate immune response of both vertebrates and invertebrates. Mammalian apolipoproteins such as apolipoprotein E (apoE) are involved in LPS detoxification, phagocytosis, and possibly pattern recognition. The multifunctional insect protein, apolipophorin III (apoLp-III), is homologous to apoE. In this study we desc...
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Recognition of nonself is the first step in mounting immune responses. In the innate immune systems of both vertebrates and arthropods, such recognition, termed pattern recognition, is mediated by a group of proteins, known as pattern recognition proteins or receptors. Different pattern recognition proteins recognize and bind to molecules (molecular patterns) present on the surface of microorga...
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CHARACTERIZATION OF THE BINDING OF APOLIPOPHORIN III TO LIPOPOLYSACCHARIDES By Merve Oztug August, 2009 Apolipophorin III (apoLp-III) is a small insect apolipoprotein used as a model. Apolipoproteins neutralize lipopolysaccharides but the details are poorly understood. Lipopolysaccharides of gram negative bacteria can induce a septic shock, a common lethal condition. In the present study, the a...
متن کاملPrimary structure and comparative sequence analysis of an insect apolipoprotein. Apolipophorin-III from Manduca sexta.
The amino acid sequence of an insect apolipoprotein, apolipophorin-III from Manduca sexta, was determined by a combination of cDNA and protein sequencing. The mature hemolymph protein consists of 166 amino acids. The cDNA also encodes for an amino-terminal extension of 23 amino acids which is not represented in the mature hemolymph protein. The existence of a precursor protein was confirmed by ...
متن کاملApolipophorin III: A Unique Insect Protein
Insect lipoprotein termed as apolipophorin III (apoLp-III), has a unique five-helix bundle protein structure. The protein is used by insects to supply high supply of energy to their flight muscles (wings) during unstopped long-distance migration. However, it is not clear why compared to most prominent four-helix bundle protein structure found in nature, apoLp-III has five helix bundles. This re...
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تاریخ انتشار 2004